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In biology, we routinely ask if certain conditions or drugs influence the 3D geometry of organisms, tissues or cells. We also want to know if the relative location of objects influences their function and properties. The new release of Imaris lets the image tell its story with stunning new aesthetic rendering tools as well as improved quantitative analysis for calculating the relative distance between pairs of object populations.
Our new release has improved Surface (reconstructions) rendering to catch the eye of the audience while showing more information so the presenter can spend more time discussing what the results mean rather than what the results are!
Try Imaris 9.5 for FreeA picture paints 1,000 words. We know that presenting your data is an important part of telling the scientific story. In Imaris 9.5 we have added stunning NEW Surfaces and Spots material options including semi-transparent ones to help you make eye-catching animations and snapshots..
For every Surfaces and Spots object Imaris 9.5 natively calculates the shortest distance to any other Surfaces or Spots. The edge of surfaces and the center of spots are used for these calculations. The computation is fast and capable of running on large images. Calculations can also be performed on multiple datasets at once in Batch mode
Native Distance Measurements are extremely useful for a variety of biological experiments and applications. Click each section to read more and find original publications and case studies highlighting this type of work.
Immunology
Tumor Microenvironment
Organoid Studies
Bone Marrow Stem Cell Niche
Organelle Distribution Inside The Cell
3D Nucleus Organization
Wound Healing
Protein Interaction
Synapse
IMMUNOLOGY
Study local anatomy of lymphoid tissues during infection. Using Imaris you can analyse intact tissue environment in situ, local pathogen specific T-cell migration, changes in the distribution of cellular populations within intact tissue or distance of selected populations to blood vessels.
Paper
https://link.springer.com/protocol/10.1007/978-1-4939-6931-9_5
Products
Imaris Single Full | Imaris for Cell Biologists
TUMOR MICROENVIRONMENT
Microscopic observation of subtle changes in tumor microenvironment is crucial to understand the mechanisms and test new cancer therapies, including immunotherapy. Use Imaris to calculate distance between dendritic cells and blood vessels in multiple samples and conditions.
Paper
https://www.sciencedirect.com/science/article/pii/S0092867418300394
Products
Imaris Single Full | Imaris for Cell Biologists
ORGANOID STUDIES
To analyse organoid you can report different properties of cells (speed, marker co-expression, volume) according to their distance to the organoid surface or center. For the organoid development studies calculate distance of different cell types to blood vessels
Paper
http://www.nature.com/articles/s41592-019-0325-y
Products
Imaris Single Full | Imaris for Cell Biologists
BONE MARROW STEM CELL NICHE
Study the distribution and potential interactions between hematopoietic stem cells (HSCs) and blood vessels using Imaris to automatically calculate shortest distance between different detected cell populations and surfaces of selected blood vessel types.
Case studies
Case Study 1 | Case Study 2
Paper
https://linkinghub.elsevier.com/retrieve/pii/S1934590918305587
Products
Imaris Single Full | Imaris for Cell Biologists
ORGANELLE DISTRIBUTION INSIDE THE CELL
Understanding intracellular interactions and dynamics between organelles such as (endoplasmic reticulum, Golgi, lysosome, peroxisome, mitochondria or lipid droplet) requires precise position and distance measurements in the 3D. Use Imaris to segment and measure distances between organelles inside the cell.
Paper
https://www.nature.com/articles/nature22369
Products
Imaris Single Full | Imaris for Cell Biologists
3D NUCLEUS ORGANIZATION
Higher order 3D nucleus organization, such as distance between DNA loci, 3D packaging of DNA in nucleus or chromosome organization during mitosis is easily analysed using Imaris segmentation and distance measurements.
Papers
https://www.nature.com/articles/srep41585
https://linkinghub.elsevier.com/retrieve/pii/S0092867418306366
WOUND HEALING
Study wound healing dynamics using Imaris. Automatically analyse migration speed and direction, proliferation and measure distance of cells to the wound surface over time.
Paper
http://www.nature.com/articles/ncb3472
Products
Imaris Single Full | Imaris for Tracking
PROTEIN INTERACTION
The interactions between protein complexes or proteins and receptors often depend on the distance between them, which can be automatically calculated in Imaris in all time points.
Paper
http://www.nature.com/articles/nsmb.3347
http://www.nature.com/articles/s41598-018-28763-6
Products
Imaris Single Full | Imaris Start
SYNAPSE
Using Imaris distance measurements you can analyse the interaction between neurotransmitters and receptor, 3D structure of pre- and post- sanaptic region.
Paper
http://biorxiv.org/lookup/doi/10.1101/568279
Products
Imaris Single Full | Imaris for Neuroscientists
In Imaris fast visualization of terabyte sized images is possible due to saving the image as a multiresolution pyramid. Then Imaris renders the image in blocks where only the resolution blocks which are required for good quality rendering on the screen are used. That is, higher resolution data are used when blocks are closer to the camera (or zoomed in) are rendered and lower resolution data are used when blocks are farther away.
The dynamic volume rendering during rotations and fast zooming are greatly improved in Imaris 9.5 because each block is rendered as a mixture of two resolution levels and this mixture changes with the distance from the camera. In prior versions each block was rendered in one of the discrete resolutions available in the pyramid.
Volume rendered as resolution blocks in Imaris 9.5: red – higher resolution, green – lower resolution. Resolution blocks smoothly morph ensuring smooth visualization.
The Imaris Learning Center hosts a wide range of tutorial videos, how-to articles and webinars to guide you through the many features of Imaris. We have provided some links below which will get you started on some of our most recent developments.
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